The new spots include a chocolate shop at Downtown Summerlin, the closures an Arts District gay bar.
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The restaurant, with choice views of the boulevard, replaces a sushi and Japanese fusion spot.
The Las Vegas native and Super Bowl champion unites Texas barbecue with Cajun and Southern standards on a stretch of Las Vegas Boulevard south of the airport.
The restaurant, named after a famous saloonkeeper during Prohibition-era Vegas, is owned by a longtime Vegas hospitality executive.
The closing comes as Vegas is otherwise having a moment for contemporary Mexican restaurants.
The restaurant blends coastal flavors, a library of tequilas and mezcals, creative cocktails, DJ sets and a beachy vibe.